标题：A Phenoxazine Compound, 2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one Reverses the Phenylephrine or High-K+ Induced Contraction of Smooth Muscles in Rat Aorta and Guinea Pig Tenia Cecum
摘要：2-Amino-4,4α-dihydro-4α-7-dimethyl-3 H -phenoxazine-3-one (Phx-1) reversed concentration dependently the contraction of both rat aorta and guinea pig tenia cecum induced by phenylephrine or high-K+. Since Phx-1 suppresses the responses of human mononuclear cells to phytohemagglutinin, (Akazawa et al. Tohoku J. Exp. Med. , 196, 185—192, 2002), Phx-1 may be useful for developing new vasorelaxing agents with immunosuppressive action.
