摘要：The anti-inflammatory effect of propolis was compared with that of diclofenac, a non-steroidal anti-inflammatory drug, and L - N G-nitro arginine methyl ester ( L -NAME), a nitric oxide synthase inhibitor, using carrageenin-induced mouse paw edema. When administered 10 min prior to carrageenin injection, propolis (1 : 1000, 1 : 100, p.o. ), diclofenac (12.5, 50 mg/kg, p.o. ) and L -NAME (10, 100 mg/kg, s.c.) showed a significant anti-inflammatory effect. The anti-inflammatory effects of propolis and L -NAME were significantly inhibited by L -arginine, a precursor of nitric oxide, but not by D -arginine. In contrast, the anti-inflammatory effect produced by diclofenac was not inhibited by either D -arginine or L -arginine. These results indicate that the anti-inflammatory effect of propolis on mouse paw edema acts via the inhibition of nitric oxide production, similar to that of L -NAME but not diclofenac.
关键词：propolis;carrageenin;paw edema; L -NG-nitro arginine methyl ester;diclofenac;mouse
