摘要：Objective: The goal of this study was to evaluate the influence of congestive heart failure (CHF) on the clearance of mexiletine. Methods: The mexiletine clearance/bioavailability (CL/F) ratio was estimated in 584 inpatients receiving mexiletine therapy. The study population consisted of 210 patients with CHF [CHF group; 116 inpatients with New York Heart Association (NYHA) class I—II (group NYHA I—II) CHF and 94 inpatients with NYHA class III—IV (group NYHA III—IV) CHF] and 374 inpatients without CHF (Non-CHF group). Serum levels of mexiletine were determined by high performance liquid chromatography (HPLC). Results: Mexiletine clearance was significantly lower in the CHF group when compared with the Non-CHF group (0.264±0.093 vs. 0.393±0.082 l/h/kg, mean±S.D., p <0.05). Further, the CL/F ratio was 50% lower in group NYHA III—IV when compared with the Non-CHF group, and the CL/F ratio tended to change in inverse proportion to NYHA class. Conclusion: CHF status significantly affects mexiletine clearance. Therefore, dose adjustments and careful monitoring are likely required in CHF patients receiving mexiletine.
关键词：clearance;congestive heart failure;New York Heart Association (NYHA);mexiletine
