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  • 标题:Microbial Contamination of Nebulization Solution and Its Measures
  • 本地全文:下载
  • 作者:Shigeharu Oie ; Daiki Makieda ; Shiro Ishida
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2006
  • 卷号:29
  • 期号:3
  • 页码:503-507
  • DOI:10.1248/bpb.29.503
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:We evaluated the microbial contamination of nebulization solutions in medication cups from a total of 76 ultrasonic nebulizers in use in 10 hospitals. In addition, an interview survey was given to nurses to evaluate the disinfection methods of these ultrasonic nebulizers. Of a total of 76 nebulization solution samples, 11 (14.5%) were contaminated with 10—102 colony-forming units (CFU)/ml and 9 (11.8%) with 103—105 CFU/ml. The major contaminants were glucose non-fermentative bacilli such as Burkholderia cepacia , CDC gr.IV C-2 , and Sphingomonas paucimobilis . Comparison of microbial contamination between the frequencies of disinfection showed a significantly lower number of contaminated samples when the cups were disinfected once daily than when disinfected once at intervals of 2—7 d ( p =0.00037). In addition, comparison between the presence and absence of preservatives contained in the nebulization solution showed a significantly lower number of contaminated samples in the presence, rather than in the absence, of preservatives ( p =0.00001). These results show that disinfection of ultrasonic nebulizers at 24-h intervals is desirable. In particular, when nebulization solutions not containing preservatives are used, disinfection at 24-h intervals is indispensable.
  • 关键词:ultrasonic nebulizer;nebulization solution;microbial contamination;disinfection
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