摘要：We have reported that transferrin (Tf)-unbound Gallium-67 (67Ga) was taken up into hepatocytes 1 d after carbon tetrachloride (CCl4)-treatment in rats. It had been reported that the binding affinity of Iron-59 (59Fe) to Tf was greater than that of 67Ga. In the present study, we investigated whether or not Tf was involved in 59Fe uptake by hepatocytes of CCl4-damaged rats. The results showed that the uptake of 59Fe by hepatocytes and the number of Tf-receptor decreased 1 d after CCl4-treatment and increased 2 d after the treatment. Our data demonstrated that the uptake of 59Fe by hepatocytes differed from that of 67Ga and Tf was involved in that of 59Fe. We expect that these finding could serve to analyze the inflammatory stages, disorder stage at 1 d and regeneration stage at 2 d after CCl4-treatment.
关键词：Iron-59 (59Fe);Gallium-67 (67Ga);non-radioactive ferric iron (NonRI-Fe);carbon tetrachloride (CCl4);hepatocyte;transferrin binding
