文章基本信息
- 标题：Bis-(2-amino-5-selenazoyl) Ketone as a Superoxide Anion-Scavenger
- 本地全文：下载
- 作者：Akihiro Sekiguchi ; Atsuyoshi Nishina ; Hirokazu Kimura 等
- 期刊名称：Biological and Pharmaceutical Bulletin
- 印刷版ISSN：0918-6158
- 电子版ISSN：1347-5215
- 出版年度：2006
- 卷号：29
- 期号：7
- 页码：1404-1407
- DOI：10.1248/bpb.29.1404
- 出版社：The Pharmaceutical Society of Japan
- 摘要：
We investigated the superoxide anion scavenging effects of 2-amino-1,3- selenazoles and bis-(2-amino-5-selenazoyl) ketones using a highly sensitive quantitative chemiluminescence method. At 166 μ M , the 2-amino-1,3-selenazoles and bis-(2-amino-5-selenazoyl) ketones scavenged in the range of 10.0 to 80.0% of O2−. Bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone exhibited the strongest superoxide anion-scavenging activity among the six kinds of 2-amino-1,3-selenazoles and three kinds of bis-(2-amino-5-selenazoyl) ketones. The 50% inhibitory concentration (IC50) of bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone was determined to be 37.1 μ M . Thus, bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone acted in vitro as effective and potentially useful O2− scavenger.
- 关键词：2-amino-1,3-selenazole; heterocycle; superoxide radical; scavenging effect; superoxide anion-scavenging activities (SOSAs)
