标题：Analysis of Relationship between Peak Inspiratory Flow Rate and Amount of Drug Delivered to Lungs Following Inhalation of Fluticasone Propionate with a Diskhaler
摘要：A Diskhaler is a dry powder type of inhaler that utilizes a breath controlled drug delivery system. The inspiratory flow rate of the patient would have a significant influence on the effects of drugs administered by a Diskhaler. Thus, we investigated the relationship between inspiratory flow rate and amount of drug delivered into the lungs when using a fluticasone propionate dry powder inhaler with a Diskhaler (FP-DH). To investigate the amount of drug inhaled, we used an inhalation simulator, which consisted of a flow recorder placed in a plastic air-tight box that covered the FP-DH equipped with a twin impinger and a vacuum pump. Drugs located in a plastic box, as well as the device, throat, and stage 1 and stage 2, were assayed by HPLC-UV, following in vitro inhalation at the various flow rates ranged from 18.7 to 77.3 l/min for 2 s. The relationship between peak inspiratory flow rate and amount of drug released from the device was analyzed. A positive linear correlation between the dose released from the device and amount of drug deposited in stage 2 was observed ( r =0.899, p <0.001). The doses deposited in stage 2 were estimated to be 2.9 μg at a flow rate of 20 l/min, 6.6 μg at 30 l/min, 8.4 μg at 40 l/min, 10.1 μg at 60 l/min, and 11.3 μg at 90 l/min. It was suggested that the amount of drug in the lungs decreased along with a decrease in peak inspiratory flow rate when it was lower than 60 l/min. Our results were found to be very useful to estimate lung deposition by using peak inspiratory flow rate for administration planning, especially in patients with a flow rate of less than 60 l/min.
关键词：fluticasone propionate;dry powder inhaler;Diskhaler;inspiratory flow rate;drug delivered to lung
