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  • 标题:Aldose Reductase and Advanced Glycation Endproducts Inhibitory Effect of Phyllostachys nigra
  • 本地全文:下载
  • 作者:Sang Hoon Jung ; Jung Min Lee ; Hee Ju Lee
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2007
  • 卷号:30
  • 期号:8
  • 页码:1569-1572
  • DOI:10.1248/bpb.30.1569
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:To evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra , eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6- C -(6″- O - trans -caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem® apparatus. It is concluded, therefore, that luteolin 6- C -(6″- O - trans -caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.
  • 关键词:aldose reductase;advanced glycation endproduct;Phyllostachys nigra;luteolin 6-C-(6″-O-trans-caffeoylglucoside);antioxidant;diabetic complications
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