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  • 标题:The Phosphoinositide Kinase PIP5K That Produces the Versatile Signaling Phospholipid PI4,5P2
  • 本地全文:下载
  • 作者:Yasunori Kanaho ; Akiko Kobayashi-Nakano ; Takeaki Yokozeki
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2007
  • 卷号:30
  • 期号:9
  • 页码:1605-1609
  • DOI:10.1248/bpb.30.1605
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The phosphoinositide kinase, phosphatidylinositol 4-phosphate 5-kinase (PIP5K), produces the versatile phospholipid phosphatidylinositol 4,5-bisphosphate (PI4,5P2), through which PIP5K plays crucial roles in a wide variety of cell functions. So far, three PIP5K isozymes and splicing variants have been identified. We speculate that each PIP5K isozyme or splicing variant is activated in a tempo-spatially different manner, due to the existence of activators or recruiters specific to each isozyme: this tempo-spatially different activation of PIP5K produces PI4,5P2 at different compartments of the cell at different times, which phenomenon may be responsible for the apparent multifunction of PI4,5P2/PIP5K. Accumulating evidence supports this notion that each PIP5K isozyme is activated by its specific activator and plays a crucial role in a unique cell function. In this article, we describe recent advances regarding the PIP5K isozyme-specific activation mechanisms and physiological functions.
  • 关键词:phosphatidylinositol 4-phosphate 5-kinase;phosphatidylinositol 4,5-bisphosphate;actin cytoskeleton;small G protein;AP-2;endocytosis
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