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  • 标题:Hepatoprotective Effect of Vitamin B12 on Dimethylnitrosamine-Induced Liver Injury
  • 本地全文:下载
  • 作者:Katsuhiro Isoda ; Noritaka Kagaya ; Soichiro Akamatsu
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2008
  • 卷号:31
  • 期号:2
  • 页码:309-311
  • DOI:10.1248/bpb.31.309
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Vitamin B12 contains a cobalt complex and accumulates at high levels in the liver. Vitamin B12 was examined for its hepatoprotective effect on dimethylnitrosamine-induced liver injury in mice. Vitamin B12 decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the liver showed that the gene expression of α-smooth muscle actin and heat-shock protein 47, which are markers of fibrosis, were suppressed by vitamin B12 administration. Our findings indicate that vitamin B12 could be an effective hepatoprotective agent.
  • 关键词:hepatoprotection;vitamin B12;liver fibrosis;metal complex
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