摘要：In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saururus chinensis , twelve lignans, sarisan (1), erythro -austrobailignan-6 (2), meso -dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel -(8 R ,8′ R )-dimethyl-(7 S ,7′ R )-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-α (TNF-α) and alanine aminotransferase (ALT) activity in mice administered LPS/ D -GalN.
