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  • 标题:Anti-methicillin Resistant Staphylococcus aureus (MRSA) Compounds Isolated from Laurus nobilis
  • 本地全文:下载
  • 作者:Nao Otsuka ; Mei-Hua Liu ; Sumiko Shiota
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2008
  • 卷号:31
  • 期号:9
  • 页码:1794-1797
  • DOI:10.1248/bpb.31.1794
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:We found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3- O -α- L -(2″,4″-di- E-p -coumaroyl)-rhamnoside (C2) and kaempferol 3- O -α- L -(2″- Z-p -coumaroyl-4″- E-p -coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae , Pseudomonas aeruginosa and Serratia marcescens .
  • 关键词:methicillin-resistant Staphylococcus aureus;Laurus nobilis;vancomycin-resistant enterococci;anti-methicillin-resistant Staphylococcus aureus compound;anti-vancomycin-resistant enterococci
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