摘要：The effect of gender on theophylline clearance was investigated retrospectively in 96 Japanese pediatric patients (63 males and 33 females) ranging in age from 0.5 to 8 years and in weight from 6.3 to 36.8 kg. All patients received intravenous constant-rate infusion of aminophylline in the asthmatic acute phase. The theophylline clearances in males and females were 56.2±15.4 and 50.1±14.2 ml/h/kg for ages 0.5—<2 years, 58.7±18.8 and 48.3±6.5 ml/h/kg for ages 2—<4 years, and 65.7±12.0 and 52.1±16.8 ml/h/kg for ages 4—<9 years, respectively. At ages from 2 to 8 years, the theophylline clearance was 20% higher in males than in females ( p <0.05). Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants.
关键词：theophylline;therapeutic drug monitoring;pharmacokinetics;clearance;gender difference;Japanese child
