摘要：Imbalance between the production and removal of reactive oxygen species (ROS) has been used for characterizing Oxidative stress. Extra amount of ROS are hazardous and can lead damages to the cells resulting in harsh diseases. For cancer, diabetes, psychological disorders and age-related disorders, latent of ROS in induction of alteration and DNA harm is a critical factor. Regarding these finding, the current research was planned to test the relationship between cognitive neuropsychological state and oxidative markers and genotoxicity in radiology staff. Total Number of 47 radiology staff, working in the radiology center of a referral University Hospital in Shiraz, were invited in the study. The participants were occupationally exposed to low-dose ionizing radiation (x-ray) for more than 2 years. Psychological disorder was analyzed by SCL-90-R. In the plasma, lipid peroxidation, DNA harm, catalase, superoxide dismutase, myeloperoxidase, and glutathione peroxidase activity were calculated. Associations between parameters were measured by using Pearson correlation coefficient and multivariate linear regression analyses. As a result, there was a positive considerable connection between catalase and paranoid ideation, Obsessive-Compulsive, Anxiety and total. Furthermore, the correlation between psychoticism, Interpersonal Sensitivity, Paranoid Ideation and DNA damage was positive. There were positive relationships between superoxide dismutase and psychomotor speed, initiative/energy, selective attention and verbal memory. So, there were significant relationships among interpersonal sensitivity, somatization, depression and gender. But, there were no major relationships among psychological distress, history workers and oxidative stress. In so many words, Oxidative stress and genotoxicity result in psychological disorders in radiology staff. So, radiology staff should have more attention, as they suffered from some psychological disorders.
