文章基本信息

标题：Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis in Vitro
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作者：Motoki Hino ; Hideaki Ichihara ; Yoko Matsumoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：11
页码：2097-2101
DOI：10.1248/bpb.b12-00633
出版社：The Pharmaceutical Society of Japan
摘要：New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C₁₂(EO)₂₁) and O , O ′-ditetradecanoyl- N -(α-trimethylammonioacetyl) diethanolamine chloride (2C₁₄ECl) were produced. Cationic HLs were smaller and more stable than pure DMPC liposomes. It is noteworthy that cationic HLs could remarkably inhibit the growth of human colon cancer (HCT116) cells along with apoptosis in vitro for the first time in this study.
关键词：hybrid liposome;colon carcinoma;apoptosis