文章基本信息
- 标题：Development of Irreversible Inactivators of Spermine Oxidase and N 1-Acetylpolyamine Oxidase
- 本地全文：下载
- 作者：Shun-suke Moriya ; Toshiyuki Miura ; Koichi Takao 等
- 期刊名称：Biological and Pharmaceutical Bulletin
- 印刷版ISSN：0918-6158
- 电子版ISSN：1347-5215
- 出版年度：2014
- 卷号：37
- 期号：3
- 页码：475-480
- DOI：10.1248/bpb.b13-00913
- 出版社：The Pharmaceutical Society of Japan
- 摘要：
Three functional groups (2-propenyl, 2-propynyl, and 2,3-butadienyl) were introduced onto one of the terminal amino groups of spermidine. Of the six compounds synthesized, N -(3-aminopropyl)- N ′-2,3-butadienyl-1,4-butanediamine ( N 8-butadienyl Spd) and N -[3-(2,3-butadienylamino)propyl]-1,4-butanediamine ( N 1-butadienyl Spd) irreversibly inactivated human spermine oxidase (SMO) and N 1-acetylpolyamine oxidase (APAO). Interestingly, N 8-butadienyl Spd inactivated SMO far more potently than N , N ′-di-2,3-butadienyl-1,4-butanediamine (MDL 72527).
- 关键词：spermine oxidase; N 1-acetylpolyamine oxidase; irreversible inhibitor; MDL 72527; polyamine catabolism
