出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Objective: To evaluate the diagnostic performance of Xpert MTB/RIF in the state of Goiás, Brazil. Methodology: Cross-sectional study based on records filed in the Mycobacteria Section of a reference laboratory in the diagnosis of diseases of interest in public health in the state of Goiás. Data were collected on samples linked to suspected cases of tuberculosis processed in the period between October 2017 and October 2018. Pulmonary and extrapulmonary samples that presented Xpert MTB/RIF results and culture were included in the study. The information collected was used to compose a database with the following variables: clinical specimen, result of Xpert MTB/RIF, result of culture and type of culture (solid or liquid). For calculating sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), growth in culture was taken as a reference. Results: 3262 samples were eligible for the study, 3068 of pulmonary origin (94.1%) and 194 of extrapulmonary origin (5.9%). The Xpert MTB/RIF showed general sensitivity and specificity of 87.1% and 97.6% for samples of pulmonary origin and 80.0% and 97.3% for samples of extrapulmonary origin. The test performance varied according to the clinical sample and the type of culture taken as a reference. Conclusion: The Xpert MTB/RIF test demonstrated in the present study to be an important diagnostic tool for cases of tuberculosis in both pulmonary and extrapulmonary samples, with good sensitivity and specificity. The results, as with any other methodology, should be interpreted with caution and based on the association of clinical, epidemiological and laboratory criteria.
