出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Atypical hemolytic uremic syndrome (aHUS) is characterized by a triad of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The pathogenesis of HUS corresponds to thrombotic microangiopathy (THA). The work aims to expose through the analysis of scientific articles the main clinical manifestations and challenges in the diagnosis of Atypical Hemolytic-Uremic Syndrome. This is a literature review of a qualitative nature based on scientific production based on studies published between 2018 and 2021. Although atypical hemolytic uremic syndrome is rare, it is related to complications and important sequelae secondary to alterations of kidney function; 42% of children and 27% of adults may have severe thrombocytopenia (<50,000 platelets/mL). Similarly, related acute kidney injury is severe in 59% of children and 81% of adults, and may be accompanied by glomerular involvement, creatinine, hematuria, proteinuria, edema, and hypertension. The treatment that is most effective against aHUS is the use of the drug Eculizumab. This drug has a high cost, but studies show an increase in life expectancy and quality of life for these patients with the use of this medication. It is necessary that more studies about this disease are carried out for the development of new diagnostic measures and therapies against aHUS at a lower cost and with easy access for the population due to the seriousness of the disease and its high mortality rate.
