标题：Complexo Acinetobacter calcoaceticus - Acinetobacter baumannii (ACB): ocorrência e perfil de resistência aos carbapenêmicos e polimixina B durante pandemia de SARS-CoV-2 em Pelotas, RS
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Bacteria of the Acinetobacter calcoaceticus - Acinetobacter baumannii (ACB) complex are a frequent cause of the so-called Healthcare-Associated Infections (HAI). During the COVID-19 pandemic, caused by the SARS-CoV-2 virus, coinfections and increased bacterial resistance to antibiotics have been observed. Thus, the present study verified the occurrence and profile of resistance to carbapenems (in the year 2020) and polymyxin B (from October 2020 to March 2021) in bacteria of the ACB complex during the SARS-CoV-2 pandemic in the Hospital School (HE) of the Federal University of Pelotas (UFPel/EBSERH). Two methodologies were applied, the identification and evaluation of bacterial susceptibility by automation (BD Phoenix), and the evaluation of resistance to polymyxin B using the microdilution panel (CIM POLYMIXIN B, Laborclin). Eighty-one isolates belonging to the ACB complex were identified, 69.1% (56) of the species A. baumannii, and 30.9% (25) of other species of the ACB complex. An increase in resistance to carbapenems from 75% in 2019 to 94.3% in 2020 was observed. Among the bacteria of the ACB complex resistant to carbapenems, 4 of them were resistant to polymyxin B. The bacteria of the ACB complex resistant to carbapenems were more frequent in the COVID-19 ICU, representing 44.9% in relation to other units. These resistant isolates were obtained from tracheal aspirate and blood samples. The data obtained reveal an increase in resistance to carbapenems, in addition to a higher incidence of positive tracheal aspirate for bacteria of the ACB complex in patients diagnosed with COVID-19, which may be related to Pneumonia Associated with Mechanical Ventilation (VAP).
