出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：The peptic ulcer is a disease characterized by a lesion on the mucous membrane of the esophagus, stomach, or duodenum, resulting from failures in the protection system of this lining, which has a high morbidity and mortality rate worldwide. It is caused both by the imbalance between the factors that damage the mucosa and those that protect it where those that damage it stand out. Spondias mombin L., popularly known as cajazeira, is used in popular medicine to treat various diseases such as conjunctivitis, healing action, antidiarrheal, diuretic, among others. Several pharmacological activities of this species have been demonstrated, such as gastroprotective, anti-inflammatory and antibacterial activities. The objective of this study was to evaluate the phytochemical composition and gastroprotective activity of the hexanic extract of Spondias mombin L. (EHCFSm) fruit peels. For this, the extract was prepared from the fruit peel by maceration (72 hours) and the solvent used was hexane. For gastroprotective evaluation rats were used, where the induction models were ethanol-induced ulcer, for the experiment we used the groups: Negative control (NaCl 0.9%) 10 mL/kg, Positive control (omeprazole) 30 mg/kg and doses of EHCFSm (100 and 200 mg/kg). Then, the animals were euthanized, the stomachs removed and analyzed with the aid of ImageJ. The results obtained in this study showed that the gastroprotective capacity of the hexanic extract of the cashew apple peels was 78.97% and 82.97% in comparison with the control group. It can be concluded that the apolar constituents of the fruit peels of Spondias mombin L. at the dose tested were effective in the model of gastroprotection in ulcer induced by ethanol in rats.
