摘要:Coronavirus Disease-2019 (COVID-19) vaccination has been Coronavirus Disease-2019 (COVID-19) vaccination has been implemented in many countries involved in developing countries. However, many factors affected the implementation. One of them was the COVID-19 vaccine literacy. This research aims to know the barrier factors related to COVID-19 vaccination literacy in developing countries. This research method is a traditional literature review from journal articles in ProQuest, Scopus, Science Direct, Google Scholar, and EBSCOhost database, published in 2013 until 2021. The steps taken in the formal review were searched for specific keywords relevant to barrier factors related to COVID-19 vaccine literacy in developing countries, conducting a review, analyzing and critical appraisal, and writing a review. Based on the research, the barrier factors related to COVID-19 vaccine literacy in developing countries were low educational degree, lack of information access, lack of digital literacy, lack of valid information, and cultural perspective. Vaccine literacy can affect the success of the COVID-19 vaccination program, especially to achieve herd immunity coverage. The government must be concerned about improving COVID-19 vaccination literacy among the communities with multi-sector collaboration.