摘要：Future generations of people worldwide will experience more frequent climate extremes, including extreme temperature, precipitation, and weather events, than current and past generations. A child born anywhere in the world in 2020 is predicted to experience 4–7 times more heatwaves during their lifetime compared with a child born in 1960.1 Extreme heat is associated with acute health effects, including excess mortality and morbidity associated with renal and respiratory diseases.2 Different climate-related events are associated with various health outcomes, including injury and infectious diseases associated with flooding or increased risk of vector-borne illnesses associated with changes in precipitation.3 To investigate how extreme climate exposures will affect human health in present and future generations of people, we propose a life course epidemiology approach to assess the relationship between climate extremes and human health (LCE-CEHH). This Comment focuses attention on the research questions and data that are necessary to answer important questions about the effects of exposure to climate extremes at each life course stage, the cumulative effect of climate exposures over a life course, and changes in the effects of exposures across birth cohorts as climate change-related exposures become more frequent and intense than in the past
