摘要：SummaryAmblyopia is a visual impairment that perturbs binocular balance at high spatial frequencies in favor of the fellow eye. Studies reveal that amblyopes who had been treated with monocular therapies still show imbalance. Binocular balance is achieved when both eyes’ inputs are weighed equally. A reduced light can diminish the dimmed eye's weight in binocular combination. In this study, we examined if binocular balance across spatial frequencies could be improved by reducing the luminance of the fellow eye in adult amblyopes. By doing so, we relieved their binocular imbalance across spatial frequencies. Also, normal observers showed amblyopic binocular imbalance when the dominant eye’s light level was dimmed. Therefore, reducing the luminance in the unaffected eye in amblyopia mitigated the binocular imbalance, whereas doing so in normal adults simulated the amblyopic imbalance across spatial frequencies.Graphical abstractDisplay OmittedHighlights•Binocular balance is impaired in amblyopia•Reduced luminance of the fellow eye can improve it across spatial frequencies in amblyopia•Reduced luminance of one eye from normal observers simulates amblyopic imbalanceBiological sciences; Neuroscience; Sensory neuroscience
