摘要：SummaryNanocarbons are often employed as coatings for neural electrodes to enhance surface area. However, processing and integrating them into microfabrication flows requires complex and harmful chemical and heating conditions. This article presents a safe, scalable, cost-effective method to produce reduced graphene oxide (rGO) coatings using vitamin C (VC) as the reducing agent. We spray coat GO + VC mixtures onto target substrates, and then heat samples for 15 min at 150°C. The resulting rGO films have conductivities of ∼44 S cm−1, and are easily integrated into anad hocmicrofabrication flow. The rGO/Au microelectrodes show ∼8x lower impedance and ∼400x higher capacitance than bare Au, resulting in significantly enhanced charge storage and injection capacity. We subsequently use rGO/Au arrays to detect dopaminein vitro, and to map cortical activity intraoperatively over rat whisker barrel cortex, demonstrating that conductive VC-rGO coatings improve the performance and stability of multimodal microelectrodes for different applications.Graphical abstractDisplay OmittedHighlights•Easy, scalable, and safe reduction method to create rGO films with vitamin C•VC-rGO coatings improve the performance of bare gold microelectrodesin vitro•VC-rGO coatings enable the voltammetric detection of dopamine on the microscale•rGO/Au electrode arrays enable high-resolution microscale recordingin vivoBioelectronics; Biodevices; Nanomaterials
