摘要：SummaryAs human populations left Asia to first settle in Oceania around 50,000 years ago, they entered a territory ecologically separated from the Old World for millions of years. We analyzed genomic data of 239 modern Oceanian individuals to detect and date signals of selection specific to this region. Combining both relative and absolute dating approaches, we identified a strong selection pattern between 52,000 and 54,000 years ago in the genomes of descendants of the first settlers of Sahul. This strikingly corresponds to the dates of initial settlement as inferred from archaeological evidence. Loci under selection during this period, some showing enrichment in Denisovan ancestry, overlap genes involved in the immune response and diet, especially based on plants. Pathogens and natural resources, especially from endemic plants, therefore appear to have acted as strong selective pressures on the genomes of the first settlers of Sahul.Graphical abstractDisplay OmittedHighlights•239 human genomes from both sides of the Wallacean ecogeographical barriers•Signals of selection are dated between -54,000 to -52,000 in modern Oceanian genomes•Genes related to immunity and diet were under strong selection•Denisovan introgressions participated to the genetic adaptations present in OceaniansBiological sciences; Genetics; Evolutionary biology; Genomics
