文章基本信息
- 标题：Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines
- 本地全文：下载
- 作者：Hirokazu SUZUKI ; Hiroyuki SAWANISHI ; Kenji YAMAMOTO 等
- 期刊名称：Chemical and Pharmaceutical Bulletin
- 印刷版ISSN：0009-2363
- 电子版ISSN：1347-5223
- 出版年度：2001
- 卷号：49
- 期号：2
- 页码：188-191
- DOI：10.1248/cpb.49.188
- 出版社：The Pharmaceutical Society of Japan
- 摘要：
On the basis of our study on the structure-activity relationships of 1, 3, 7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.
- 关键词：phosphodiesterase 4 inhibitor; 3-phenylxanthine; 4-phenyl[i]condensed-purine
