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  • 标题:Development and Application of a Solution-Phase Automated Synthesizer, ‘ChemKonzert’
  • 本地全文:下载
  • 作者:Kazuhiro Machida ; Yoichiro Hirose ; Shinichiro Fuse
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2010
  • 卷号:58
  • 期号:1
  • 页码:87-93
  • DOI:10.1248/cpb.58.87
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    In this paper we describe the development of a fully-automated solution-phase synthesizer, ‘ChemKonzert’ that can be used to prepare a wide variety of organic compounds. The automated synthesizer is ingeniously designed to perform most of the chemical reactions currently used by synthetic organic chemists and utilizes a centrifugal separator to efficiently achieve liquid-liquid extraction. The design of the hardware and software will be described in this paper, and several examples of organic reactions will also be presented as applications of the apparatus.

  • 关键词:solution-phase synthesis; automated synthesizer; centrifugal separator; ChemKonzert; application example
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