文章基本信息
- 标题：Synthesis and Configurational Stability of ( S )- and ( R )-Deuteriothalidomides
- 本地全文：下载
- 作者：Takeshi Yamamoto ; Etsuko Tokunaga ; Shuichi Nakamura 等
- 期刊名称：Chemical and Pharmaceutical Bulletin
- 印刷版ISSN：0009-2363
- 电子版ISSN：1347-5223
- 出版年度：2010
- 卷号：58
- 期号：1
- 页码：110-112
- DOI：10.1248/cpb.58.110
- 出版社：The Pharmaceutical Society of Japan
- 摘要：
3′-Deuteriothalidomide was synthesized and found to be configurationally five times more stable than thalidomide toward racemization at physiological pH.
- 关键词：thalidomide; isostere; deuterium
