Four new 2-arylbenzofuran derivatives, moracins V—Y (1—4), together with two known compounds, moracin N (5) and moracin P (6), were isolated from the leaves of Morus alba L. Their structures were elucidated by spectroscopic analysis. Moracins X (3) and Y (4) represent unusual substituted group compared with 2-arylbenzofuran derivatives, which were isolated from the genus Morus . Compounds 2—5 were evaluated for cytotoxicity against several human cancer cell lines.