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  • 标题:Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N -Sulfinyl Imines
  • 本地全文:下载
  • 作者:Tito Akindele ; Ken-ichi Yamada ; Takumi Sejima
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2010
  • 卷号:58
  • 期号:2
  • 页码:265-269
  • DOI:10.1248/cpb.58.265
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Enantiomerically enriched sulfonamides were synthesized by the radical addition of an acetal to enantiomerically pure N -sulfinyl imines using dimethylzinc–air and boron trifluoride diethyl etherate. Higher levels of stereocontrol were observed by using a mesitylenesulfinyl group. Furthermore, an amine and an amino alcohol with high enantiomeric purity were obtainable from the sulfonamide product.

  • 关键词:asymmetric synthesis; radical reaction; dimethylzinc; sulfonamide
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