摘要：Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability.
Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of
H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that
H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with
H. erinaceus mycelium. In addition,
H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium.
H. erinaceus mycelium shows promise as a functional food in the treatment of OA.
