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  • 标题:Synthesis of Tetrahydrofuro[2,3-d]oxazoles and Oxazoles by Hypervalent Iodine (III)-Promoted [2 + 2 + 1] Annulation
  • 本地全文:下载
  • 作者:Hiroaki Ishida ; Shoya Homma ; Ryota Kasuga
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2022
  • 卷号:70
  • 期号:3
  • 页码:192-194
  • DOI:10.1248/cpb.c21-01001
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Reaction of a hypervalent iodine reagent with bistriflimide efficiently promotes three-component regioselective cyclization of tetrahydrofuro[2,3-d]oxazoles and oxazoles from homopropargyl alcohols bearing a phenyl group, with different substituents on the aryl alkyne compounds affecting the selectivity of the resulting product. Utilizing the hydroxyethyl oxazole derivatives obtained in this research could aid in the development of various peroxisome proliferator-activated receptor agonist derivatives.
  • 关键词:hypervalent iodine;[2 + 2 + 1] annulation;tetrahydrofuro[2;3-d]oxazole;oxazole
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