期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：1
页码：2891-2895
DOI：10.9756/INT-JECSE/V14I1.347
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Background: The genus Capnocytophaga consists of seven species which inhabit the oral cavity of humans or domestic animals.Capnocytophaga gingivalis, Capnocytophaga ochracea, Capnocytophaga sputigena, Capnocytophaga granulosa and Capnocytophaga haemolytica are inhabitants of the human oral cavity and have been associated with periodontitis. Therefore, the present study was done as an insilico approach towards identification of virulence factors in Capnocytophaga canimorsus targeted by hypericin. Materials and Methods: VICMPred classifies the proteins into four major classes namely, virulence factors, information and storage processing, cellular process and metabolism. The virulence factors are identified based on the support vector machine (SVM) algorithm which classifies proteins based on their amino acid composition and sequence pattern. Results: The interaction of the phytocompound hypericin showed weak interactions with five different proteins of Capnocytophaga canimorsus. Most of these proteins were involved in cellular process and metabolism. All the proteins identified using the computational tools were predicted to be Avirulent which is evident from the negative score values. Conclusion: Target and lead discovery constitute the main components of today's early pharmaceutical research. The aim of target discovery is the identification and validation of suitable drug targets for therapeutic intervention, whereas lead discovery identifies novel chemical molecules that act on those targets. Also, this study opens up potential testing (in-vitro and in-vivo) possibilities for this compound against Capnocytophaga canimorsus.
