期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：2
页码：1944-1955
DOI：10.9756/INT-JECSE/V14I2.172
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Septic shock results when infectious microorganisms in the bloodstream induce a profound inflammatory response causing hemodynamic decompensation. This inflammatory response causes activation of leukocytes and endothelial cells, as well as activation of the coagulation system. The excessive inflammatory response that characterises septic shock is driven primarily by the cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1), which are produced by monocytes in response to an infection. The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites. It may be located in any part of the body, but most commonly in the lungs, brain, urinary tract, skin or abdominal organs. It can cause multiple organ dysfunction syndrome and death.
