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  • 标题:Red Blood Cells Alloimmunization and Autoimmunization in Transfusion-dependent B-thalassemic Children at Zagazig University Hospital
  • 本地全文:下载
  • 作者:MervatAtfy Mohammed ; Ahmed Emam ; Heba Hassan Gawish
  • 期刊名称:International Journal of Early Childhood Special Education
  • 电子版ISSN:1308-5581
  • 出版年度:2022
  • 卷号:14
  • 期号:3
  • 页码:1254-1262
  • DOI:10.9756/INT-JECSE/V14I3.149
  • 语种:English
  • 出版社:International Journal of Early Childhood Special Education
  • 摘要:Background: Thalassemia is a congenital hemolytic disorder, caused by a partial or complete defect in alpha or beta globin chain synthesis. The globin chains that are produced in relative excess can damage the RBCsIn absence of stem cell transplantation the disease is treated by life-long RBC transfusion to keep the hemoglobin level 9 to 11.5g/dL. T he identification of alloantibodies in the recipient's serum makes further transfusion safer as compatible blood can provided. Aim of work: to screen for alloantibodies and autoantibodies against red cell antigens. Methods: Our study included 100 multi transfused thalassemic patients. 52 males And 48 femalesaged from 1 to 16. Results: Alloantibody was negative in 82% of cases, and positive in 18% of cases of positive cases 61.1% Anti E, 16.7% non-specific, 11.1% Anti E and Anti jkb and 11.1% Anti E and Anti C. Autoantibody was positive in 38% of patients. There is no statistically significant difference between patients with negative and positive alloantibodies as regard sex, age nor consanguinity, age at 1st blood Transfusion, splenectomy, blood group, Rh, hepatitis viral screening or receiving non-leukodepleted blood. There is significant difference between patients as regard time interval, transfusion frequency.There is significant difference between patients with positive and negative alloantibodies as regards diagnosis.The antibodies to Rh system antigens (anti-E and anti-C) were detected most frequently which reflect the greater immunogenicity of these red cell antigens.According to these results current guidelines for matching by ABO, Rh and Kell systems compared to blood phenotypically matched for the standard ABO-D is to be effective in preventing alloimmunization in patient with thalassemia. Conclusion: alloimmunization to red blood cell antigens are frequent finding and quite relevant among Egyptian transfusion-dependent thalassemic patients. The most frequent antibodies detected were anti-E. The majority of alloantibodies detected were clinically significant. Autoimmunization was frequent finding in our study. There are several factors that might have contributed to the problem including exposure to multiple allogenic blood with majority of patients were transfused with blood matched for ABO&D antigens only, the absence of phenotypically matched donors and transfusion of non leukodepleted red blood cells, along with recipient's immune status consider risk factors for the alloimmunization.
  • 关键词:Red Blood Cells Alloimmunization;Autoimmunization in Transfusion;dependent B;thalassemic Children
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