期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：3
页码：1071-1077
DOI：10.9756/INT-JECSE/V14I3.131
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Background: Beta thalassemia is considered the most common hereditary chronic hemolytic anemia in Egypt as about one thousand per 1.5 million live birth has thalassemia with estimation 10% as rate of carrier. Short stature between pediatric patients of beta thalassemia is a problem in developing countries due to several factors, like inadequate blood transfusion, iron overload, deferoxamine toxicity, hypothyroidism, abnormal growth hormone (GH) secretion, zinc deficiency, inadequate treatment, and non-adherence. Leptin,is an adipokine which is synthesized and released from adipocytes in response to changes in body fat and binds receptors within the hypothalamus to control appetite. Leptin is considered a physiological link between nutritional status and reproductive maturation and function. So sexual development may be triggered by liptin which can be a metabolic gate of it.We conducted this study to evaluate the relation between serum leptin and growth and puberty in pediatric beta thalassemia patients who are transfusion dependent. Methods:We selected 33 case of pediatric patients of beta thalassemia above age of eight years and had delayed growth, and we exclude all individuals suffering from any problem affecting growth and development. Our patients were being followed up at hematologic outpatient clinics in Zagazig University hospital and Mansoura insurance hospital, in the period from December, 2018 to June, 2020. We compared them by 28 healthy controlled individuals sharing the same age and sex who attended outpatient general clinics. Results:Our results revealed significant decrease of serum leptin in patients of thalassemia comparing with healthy control but there was no significant correlation between this and delayed growth and puberty. Serum ferritin and BMI had the upper hand of correlation with leptin (being -ve and +ve correlation respectively) more than other factors. Also we noticed that the most delayed growth cases had the least levels of leptin. Conclusion:Leptin is significant low in transfusion dependent beta thalassemia patients (312:741 pg /ml) in comparison with control (1263:2633 pg/ml). There is significant negative correlation between serum leptin and ferritin in beta thalassemia: rs=545- and p value (.001). No significant correlation between serum leptin and delayed growth in beta thalassemia inspite of low level of liptin in pubertal patient than control individus of the same age catigor. Associated endocrinal disorders as hypothyroidism may participate in growth and pubertal delay in transfusion dependent thalassemia patients.
