期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：3
页码：810-813
DOI：10.9756/INT-JECSE/V14I3.102
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Aim The objective of this clinical study was designed to determine the effect of pentoxifylline on progression of oral submucous fibrosis while comparing it to the placebo treatment. Methodology 75 patients suffering from oral submucous fibrosis were randomly divided into two groups A and B. Group A patients received placebo, while Group B patients received 400 mg. Pentoxifylline for a period of 7 months. Treatment outcome was evaluated on the basis of improvement in symptom and sign scores. Student’s ‘t’ test was applied for comparing the results. Results The improvement in total (i.e. symptoms + sign) score was 25% in group A and 49.15% in group B. This difference was found to be statistically significant. (p < 0.05) Conclusion Treatment regimen of group B was more effective. No significant side effects were seen. A follow up study is required to assess long term outcome of this therapy.
