期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：5
页码：4610-4617
DOI：10.9756/INTJECSE/V14I5.556
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Due to its well-known benefits, propofol is one of the most commonly used medications for paediatric sedation; yet, significant concerns exist regarding respiratory and/or cardiac problems in propofol-treated kids. Propofol is being used off-label for this use in many countries, despite the fact that numerous studies have been done to compare it to other sedative drugs or opioids for children undergoing various procedures. Materials and methods: In order to offer a comprehensive summary of the data that might be taken into account we conducted a systematic review and meta-analysis of those studies. All the studies conducted before 2019 were included from the online sources like “MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials”. Results: The included thirty studies revealed that propofol sedation was superior to other medications in terms of recovery time without raising too many concerns about adverse cardiovascular or respiratory events. Its safety profile in terms of delirium, vomiting, or nausea was comparable to that of other medications. Conclusion: The evidence as a whole indicates that regulatory decisions regarding propofol sedation for paediatric procedures should be viewed more favorably.
