出版社：National Institute of Occupational Safety and Health
摘要：The aim of this study was to investigate the effects of noise on hearing, lipid peroxidation and antioxidant enzymes in textile workers. Thirty textile workers exposed to high noise 105 dB (A) in a textile factory, and 30 healthy male volunteers in our hospital as a control group were included in the study. In both groups, following audiometric tests, blood samples were obtained. In these blood samples, Malonydialdehyte (MDA), Superoxide dismutase (SOD) and Catalase (CAT) levels were investigated. Statistical analysis was performed by using SPSS version 11.0 (SPSS Inc., Chicago 1L) software program. Mean pure tone audiometric thresholds in workers were significantly higher than in control subjects at frequencies 2,000, 4,000 and 6,000 Hz ( p <0.05). Hearing losses were more evident at high frequencies (4-6 kHz) than at low frequencies in worker group. ( p <0.05). It was observed that textile workers with longer employment duration had poorer hearing threshoulds and the hearing loss had started on those who had worked for 5-8 yr. While MDA levels were significantly higher in workers than controls ( p <0.001), CAT activity was significantly lower ( p <0.005). Also, SOD activity was lower in workers but difference was not statistically significant. We observed a significant change in hearing threshold of the textile workers compared with that of the control group. Increase in MDA level and decreases in CAT and SOD activities in textile workers, support the opinion that the noise causes the oxidative stress. The fact that noise both causes hearing loss and increases oxidative stress suggests that there may be a relationship between the oxidative stress and hearing loss. But, further studies are needed in order to verify this opinion.
