出版社：National Institute of Occupational Safety and Health
摘要：Cadmium in blood (Cd-B) is an important indicator, next to Cd in urine, in biological monitoring of exposure to Cd. The present study was initiated to examine compatibility in results of analysis for Cd-B between graphite furnace atomic absorption spectrophotometry (GFAAS) and inductively-coupled plasma mass-spectrometry (ICP-MS). For this purpose, 1,159 blood samples were collected from adult women (with no occupational exposure to Cd) in eight prefectures nation-widely in Japan. The samples were analyzed by the two methods; geometric mean (the maximum) concentrations were 1.22 (6.90) μ g/l by ICP-MS, and 1.47 (7.40) μ g/l by GFAAS. Statistical analyses showed that there was a close correlation between the results by the two methods. The regression line (with ICP-MS and GFAAS results as an independent variable and a dependent variable, respectively) had a slope close to one and an intercept next to zero to suggest that ICP-MS gave values compatible with that of GFAAS. Further analysis with the ratio of Cd-B by GFAAS over that by ICP-MS revealed that the two results were close to each other, and that the agreement was even closer when Cd-B was >2 μ g/l. Thus, the two methods can be employed inter-convertibly when Cd-B is relatively high, e.g. >2 μ g/l. Care may need to be practiced, however, for possible ‘between methods’ difference when Cd-B is low, e.g., ≤2 μ g/l.
关键词：Blood;Cadmium;GFAAS;ICP-MS;Population with no occupational exposure
