摘要：SummarySmartphones offer unique opportunities to trace the convoluted behavioral patterns accompanying healthy aging. Here we captured smartphone touchscreen interactions from a healthy population (N = 684, ∼309 million interactions) spanning 16 to 86 years of age and trained a decision tree regression model to estimate chronological age based on the interactions. The interactions were clustered according to their next interval dynamics to quantify diverse smartphone behaviors. The regression model well-estimated the chronological age in health (mean absolute error = 6 years, R2 = 0.8). We next deployed this model on a population of stroke survivors (N = 41) to find larger prediction errors such that the estimated age was advanced by 6 years. A similar pattern was observed in people with epilepsy (N = 51), with prediction errors advanced by 10 years. The smartphone behavioral model trained in health can be used to study altered aging in neurological diseases.Graphical abstractDisplay OmittedHighlights•A smartphone data-driven model was trained to estimate chronological age•The model trained in health performed well to estimate the age•The same model estimated advanced aging in stroke and epilepsy•Smartphone-based model of healthy behavior may help understand aging in diseasesComputing methodology; Health technology; Neuroscience
