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  • 标题:Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection
  • 本地全文:下载
  • 作者:Michail Spanos ; Sigal Shachar ; Thadryan Sweeney
  • 期刊名称:iScience
  • 印刷版ISSN:2589-0042
  • 出版年度:2022
  • 卷号:25
  • 期号:8
  • 页码:1-13
  • DOI:10.1016/j.isci.2022.104833
  • 语种:English
  • 出版社:Elsevier
  • 摘要:SummaryPatients with SARS-CoV-2 infection (COVID-19) risk developing long-term neurologic symptoms after infection. Here, we identify biomarkers associated with neurologic sequelae one year after hospitalization for SARS-CoV-2 infection. SARS-CoV-2-positive patients were followed using post-SARS-CoV-2 online questionnaires and virtual visits. Hospitalized adults from the pre-SARS-CoV-2 era served as historical controls. 40% of hospitalized patients develop neurological sequelae in the year after recovery from acute COVID-19 infection. Age, disease severity, and COVID-19 infection itself was associated with additional risk for neurological sequelae in our cohorts. Glial fibrillary astrocytic protein (GFAP) and neurofilament light chain (NF-L) were significantly elevated in SARS-CoV-2 infection. After adjusting for age, sex, and disease severity, GFAP and NF-L remained significantly associated with longer term neurological symptoms in patients with SARS-CoV-2 infection. GFAP and NF-L warrant exploration as biomarkers for long-term neurologic complications after SARS-CoV-2 infection.Graphical abstractDisplay OmittedHighlights•40% of hospitalized patients with COVID-19 developed neurological sequelae after recovery•Age, disease severity, and COVID-19 infection were associated with neurological sequelae•GFAP and NF-L were significantly elevated in SARS-CoV-2 infection compared to controls•GFAP and NF-L were elevated in patients with long-term neurological symptomsImmunology; Neuroscience
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