摘要：Aim: To assess the efficacy of Vitamin E, Melatonin and Bleomycin in leukoplakia management. Materials & Methods: This observational prospective study comprised of 45 patients of oral leukoplakia and divided into 3 groups of 15 samples in each group. Group I patients were prescribed Vit E, Group II with Melatonin and Group III with Bleomycin. The clinical and histological improvement was recorded till 6 months follow up. Collected data were statistically analyzed using SPSS software version 22. P value less than 0.05 was considered significant. Results: Complete improvement of leukoplakia was seen in 3, 6 and 4 patients, in group I , II and group III respectively. Partial improvement was seen in 3,7 and 5 patients in group I ,II and group III respectively. Better clinical response was observed with Melatonin (Group I) followed by Bleomycin (Group II) and Vit E (Group II). In group I, for post treatment, 7 cases were normal, 5 cases had atypical hyperplasia, 3 had mild dysplasia and 1 were moderate dysplasia. In group II during post treatment, 13 were normal, 2 had atypical hyperplasia, 0 were mild dysplasia. In group III during post treatment, 9 were normal, 6 had atypical hyperplasia, 0 were mild dysplasia. Post treatment improvement in group I (p>0.01), and II (p>0.4) was statistically significant. Conclusion: Authors found that Vit E, Bleomycin, and Melatonin are useful and effective in managing cases of oral leukoplakia.
