期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2022
卷号：119
期号：34
DOI：10.1073/pnas.2207767119
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Significance
Anchoring soft millirobots on surfaces, such as biological tissues, is essential to perform long-duration medical functions robustly on a target position. For robust anchoring, we propose a wireless mechanism that can be precisely controlled by remote heating to achieve on-demand needle release and mechanical interlocking. Such a mechanism can be easily integrated on existing untethered soft robots, allowing them to anchor robustly to soft surfaces while retaining their locomotion capabilities. Furthermore, we demonstrate advanced functionalities of such robots, such as controlled surface detachment and subsurface drug delivery into three-dimensional cancer spheroids. Given these capabilities, the proposed mechanism can serve as a platform for the development of soft robots with a new suite of biomedical capabilities.
Untethered soft miniature robots capable of accessing hard-to-reach regions can enable new, disruptive, and minimally invasive medical procedures. However, once the control input is removed, these robots easily move from their target location because of the dynamic motion of body tissues or fluids, thereby restricting their use in many long-term medical applications. To overcome this, we propose a wireless spring-preloaded barbed needle release mechanism, which can provide up to 1.6 N of force to drive a barbed needle into soft tissues to allow robust on-demand anchoring on three-dimensional (3D) surfaces. The mechanism is wirelessly triggered using radio-frequency remote heating and can be easily integrated into existing untethered soft robotic platforms without sacrificing their mobility. Design guidelines aimed at maximizing anchoring over the range of the most biological tissues (kPa range) and extending the operating depth of the device inside the body (up to 75%) are also presented. Enabled by these advances, we achieve robust anchoring on a variety of ex vivo tissues and demonstrate the usage of such a device when integrated with existing soft robotic platforms and medical imaging. Moreover, by simply changing the needle, we demonstrate additional functionalities such as controlled detachment and subsurface drug delivery into 3D cancer spheroids. Given these capabilities, our proposed mechanism could enable the development of a new class of biomedical-related functionalities, such as local drug delivery, disease monitoring, and hyperthermia for future untethered soft medical robots.
关键词：enWireless medical robotssoft robotsminiature robotssurface anchoringmedical devices
