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  • 标题:A Regio- and Stereo-selective Parallel Synthesis of Five Types of Trigalactoses on a Solid Support as a Model of a Combinatorial Oligosaccharide Library
  • 本地全文:下载
  • 作者:Shiro Komba ; Takeshi Terauchi ; Sachiko Machida
  • 期刊名称:Journal of Applied Glycoscience
  • 印刷版ISSN:1344-7882
  • 电子版ISSN:1880-7291
  • 出版年度:2011
  • 卷号:58
  • 期号:1
  • 页码:1-12
  • DOI:10.5458/jag.jag.JAG-2010_006
  • 出版社:The Japanese Society of Applied Glycoscience
  • 摘要:

    A regio- and stereo-selective parallel synthesis of oligosaccharides on a solid support was successfully achieved by a combination of a novel α -selective glycosidation procedure and a uni-chemo hydroxyl protection (UCHP) procedure. The α -selective glycosidation of dibutyl 3,4-di- O -benzoyl-2,6-di- O -benzyl- α / β -D-galactopyranosyl phosphate in cyclopentyl methyl ether (as an ethereal solvent for effective swelling of the polystyrene resin) proceeded smoothly and in relatively high yield. Five types of trigalactoses [Gal α 1-3Gal β 1-3Gal, Gal β 1-3(Gal α 1-4)Gal, Gal α 1-4Gal β 1-3Gal, Gal α 1-3Gal β 1-4Gal, and Gal α 1-4Gal β 1-4Gal] were successfully synthesized on a solid support as a model of a combinatorial oligosaccharide library.

  • 关键词:combinatorial oligosaccharide library; regio- and stereo-selective synthesis; uni-chemo hydroxyl protection
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