期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2004
卷号：35
期号：1
页码：47-52
DOI：10.3164/jcbn.35.47
出版社：The Society for Free Radical Research Japan
摘要：We present here current data on the distribution and metabolism of vitamin E analogs in vivo . There are eight different naturally occurring forms of vitamin E: four tocopherols (α-, β-, γ-, and δ-Toc) and four tocotrienols (α-, β-, γ-, and δ-Toc-3). With regard to the bioavailability of vitamin E, it has been established that the affinity of various vitamin E analogs for α-tocopherol transfer protein (α-TTP), which may determine their plasma levels, is a major determinant of their biological activity. However, a novel function of Toc-3 has been noted as a result of its unique distribution in the skin and the adipose tissue. In addition, following the discovery that the final metabolites of Toc and Toc-3 are in the form of carboxyethyl hydroxychroman, it is now possible to examine the intermediary metabolites of vitamin E analogs. The metabolism of vitamin E is known to be involved in the actions of drug metabolic enzymes (CYP3A, CYP4F2). However, the relationship between α-TTP and the metabolic enzymes that are responsible for the regulation of vitamin E metabolism has yet to be clarified. Future research will focus on the elucidation of the vitamin E metabolic regulation system.
关键词：tocopherol;tocotrienol;carboxyethyl-hydroxychorman;vitamin E metabolism
