期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2005
卷号：36
期号：3
页码：83-89
DOI：10.3164/jcbn.36.83
出版社：The Society for Free Radical Research Japan
摘要：To survey the risk factors in multi-infarct dementia (MID), the levels of fatty acids in serum were measured for MID patients and compared with those of healthy individuals. Examined were 40 MID patients aged 57-94 and 152 healthy control subjects aged 50-89. The mean levels of polyunsaturated fatty acid (PUFA), monounsaturated fatty acid and saturated fatty acid of MID were lower than those of the control subjects ( p <0.001, respectively). The total amounts of n-3 PUFA and n-6 PUFA in MID were significantly lower than those in control subjects ( p <0.01 and p <0.05, respectively) but there were no differences among those of the ratios of n-3/n-6 PUFA. When compared with those of control subjects, low eicosapentaenoic acid (EPA, C20:5n-3) and high arachidonic acid (AA, C20:4n-6) were found in MID ( p <0.001, respectively). No significant differences were found in the mean levels of docosahexaenoic acids (DHA, C22:6n-3) between MID and control subjects. The levels of EPA/AA and DHA/AA ratios were lower and the levels of DHA/EPA ratios were higher for the MID than for the control subjects ( p <0.001, p <0.01, and p <0.001, respectively). The EPA/AA ratios showed a positive correlation with the DHA/AA ratios in MID patients and control subjects ( r =0.65 and r =0.77, p <0.001, respectively). The ratios of DHA/AA showed a positive correlation with the DHA/EPA levels in control subjects ( r =0.25, p <0.01), but there was no correlation in the dementia patients. These results suggest that the low EPA and high AA levels and the high DHA/EPA and low DHA/AA ratios might be useful indicators of MID.
