期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2006
卷号：38
期号：2
页码：103-106
DOI：10.3164/jcbn.38.103
出版社：The Society for Free Radical Research Japan
摘要：The effects of long-term supplementation with 1α-hydroxyvitamin D3 (1α (OH) D3) on serum pepsinogen (PG) I levels, and Helicobacter pylori ( H. pylori ) infection rate, were investigated in healthy elderly women, aged 70 to 99 years, in a nursing home. Of these 34 subjects, 15 have been administered one microgram of 1α (OH) D3 daily for twenty years, because of osteoporosis treatment, and 19 were free from the drug. Serum PG-I levels and H. pylori infection rate in subjects with 1α (OH) D3 were significantly lower than those without treatment (p<0.05). These results suggested the inhibitory effect of long-term administration of 1α (OH) D3 on H. pylori infection.
关键词：1α-hydroxyvitamin D3;Helicobacter pylori;pepsinogen I;elderly women;nursing home
