期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2006
卷号：38
期号：3
页码：127-132
DOI：10.3164/jcbn.38.127
出版社：The Society for Free Radical Research Japan
摘要：Nonalcoholic steatohepatitis (NASH) is a clinicopathological condition that comprises a wide spectrum of liver damage, ranging from steatohepatitis, advanced fibrosis and cirrhosis. NASH is the most common liver disease in the United States, with a high prevalence in the obese, type 2 diabetic population and metabolic syndrome. Although the pathophysiology of NASH remains to be clarified, insulin resistance, free fatty acids and oxidative stress are the most important causes. In this review article, I focused on insulin resistance, free fatty acids and oxidative stress as main causes of NASH, and described the outlines of the pathophysiology of NASH.
