期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2006
卷号：38
期号：3
页码：133-137
DOI：10.3164/jcbn.38.133
出版社：The Society for Free Radical Research Japan
摘要：Epidemiologic studies have demonstrated acute and serious adverse effects of particulate air pollution on respiratory health, especially in people who are susceptible to bacterial infection. The underlying mechanism remains to be elucidated. Diesel exhaust particles (DEP) derived from diesel engine-powered automobiles are major constituents of the atmospheric particular matter in metropolitan areas. DEP reportedly enhance airway inflammation and lung injury. Bacterial endotoxin in a purified form known as lipopolysaccharide is also implicated as an environmental factor that exacerbates lung diseases. In this article, we review the synergistic enhancing effects of DEP and bacterial endotoxin on airway inflammation and determine the components in DEP responsible for these effects. Oxygen free radicals and proinflammatory cytokines are proposed mediators for DEP-induced airway inflammation. We elucidate the role of oxidative stress and proinflammatory cytokine expression in the enhancement.
